I AM greatly honored with your invitation to address you on the history of the discovery of radioactive iodine and its early use in studies of thyroid function, especially the part in which I was involved with Robley Evans, when we defined the single effective dose of radioactive iodine, used alone and without other therapy, and also produced near-total destruction of then thyroid by intentional over-treatment with a single dose.
Seated about our table were Professor J. Chapman EM. Coronavirus Resource Center. Our website uses cookies to enhance your experience. By continuing to use our site, or clicking "Continue," you are agreeing to our Cookie Policy Continue.
The American Weekly , June 2, , quoted Dr. Seidlin to be the Associative Director. His brother Dr. Roy Hertz was the oncologist.
Eugene Nelson was the Physicist Figure September 9, announcement of the world's first Radioactive Isotope Institute. Dr Saul Hertz established the institute and served as the director. Boston Globe August 3, "atomic cocktail" cured cancer. We have a large family. Many were praying for me. The cure delivered on the wings of prayer was Dr.
Saul Hertz's discovery, the miracle of radioactive iodine. Few can equal such a powerful and precious gift. Licensee IntechOpen. This chapter is distributed under the terms of the Creative Commons Attribution 3. Help us write another book on this subject and reach those readers. Login to your personal dashboard for more detailed statistics on your publications.
By Syed Mudassar, Mosin S. Khan, Shariq R. Masoodi, Khursheed A. While there Livingood co-discovered iodine and many other isotopes.
He helped design and construct the earliest cyclotron, a type of accelerator used to separate subatomic particles. It did not take the scientific community long to put Seaborg's and Livingood's discovery of iodine to use. By , a paper had been published outlining its potential for medical diagnostic use.
In , it was first used to treat thyroid cancer. The next year, it was used to probe the brain for tumors. By , iodine was being used for cardiac blood flow imaging.
Iodine became the first radiopharmaceutical approved for use by the FDA in In , it was used for diagnosing liver problems and in , it was first used to treat malignant melanoma. Dell Markey is a full-time journalist.
Hypothyroidism could be reduced if the normal tissue was protected by the direct injection of the radioiodine into the nodule under ultrasound control [ 23 ]. A similar anatomical approach using radiofrequency ablation is already being used with success [ 24 , 25 ]. Radioiodine for the treatment of thyroid disorders has been the success story of nuclear medicine.
It involves the use of an economic readily available radionuclide which is highly concentrated by the thyroid gland. The results of its use in the treatment of differentiated cancer of the thyroid are excellent, acting as a model for molecular radiotherapy.
In spite of being in clinical use for 75 years, there are still areas for research which could improve the outcomes in benign and malignant thyroid disease. The idea of using fixed activities and activities calculated based on body weight seem illogical and are based on the experience of drug therapy where the drug diffuses throughout the body.
In contrast, radiopharmaceuticals target and concentrate in pathologies and organs and it is the absorbed dose from the tissue uptake that is important. In external beam radiation therapy, the major effort is in delivering radiation in the most effective manner and minimizing side-effects by using the appropriate dose and a treatment plan.
Perhaps it is time to review our approach to molecular radiotherapy, especially for thyroid disease where we have a radionuclide with high concentration and the means of measuring its physiology in real time and with high resolution. Hertz S, Roberts A. Radioactive iodine in the study of thyroid physiology; the use of radioactive iodine therapy in hyperthyroidism.
J Am Med Assoc. Mazzaferri E. A randomized trial of remnant ablation--in search of an impossible dream? J Clin Endocrinol Metab. Webb S. From the watching of shadows: the origins of radiological tomography. Smithers DW. Some varied applications of radioactive isotopes to the localization and treatment of tumors. Acta Radiol. Siegel E. The beginnings of radioiodine therapy of metastatic thyroid carcinoma: a memoir of Samuel M.
Seidlin, M. Cancer Biother Radiopharm. Guidelines for radioiodine therapy of differentiated thyroid cancer. Ablation with low-dose radioiodine and thyrotropin alfa in thyroid cancer. N Engl J Med. Assessment of the efficacy of iodine for thyroid ablation.
J Nucl Med. CAS Google Scholar. Long-term outcomes following low-dose radioiodide ablation for differentiated thyroid cancer.
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